College football picks: Another week for an unranked underdog upset in the Top 25?

If this week is similar astir others successful assemblage shot the past 2 years, astatine slightest 1 unranked double-digit underdog volition sound disconnected a squad successful The Associated Press Top 25.

Since Florida State bushed then-No. 8 Alabama arsenic a 13.5-point underdog, astatine slightest 1 unranked double-digit 'dog has beaten a ranked hostile six of the archetypal 10 weeks of the season. None was arsenic shocking arsenic winless UCLA's triumph implicit No. 7 Penn State arsenic a 25.5-point 'dog.

In 2024, astatine slightest 1 unranked double-digit underdog took down a Top 25 squad successful 10 of the 14 weeks of the regular season. Florida State was progressive successful the archetypal 1 past year, too. The then-No. 10 Seminoles were connected the incorrect extremity of a 24-21 score against 10.5-point underdog Georgia Tech successful Ireland.

The picks for this week’s FBS vs. FBS games, with Top 25 rankings and lines from BetMGM Sportsbook:

This isn't the week Purdue ends its school-record 15-game losing streak successful Big Ten games. Look for Ohio State QB Julian Sayin to pad his Heisman Trophy resume.

Pick: Ohio State 45-10.

Hoosiers person hung 50-plus points connected 3 of their six Big Ten opponents. The Nittany Lions won't fto that happen, but neither volition they beryllium capable to support up with this juggernaut.

Pick: Indiana 38-17.

Aggies person scored 135 points successful their 3 roadworthy games and volition bring the vigor against Mizzou freshman Matt Zollers, who'll marque his archetypal commencement successful spot of the injured Beau Pribula.

Pick: Texas A&M 27-21.

So overmuch has gone connected successful Baton Rouge the past 2 weeks, the “First Saturday successful November” rivalry crippled hasn't had the accustomed buildup. All the unit is connected the Crimson Tide, and they'll respond.

Pick: Alabama 31-14.

Mississippi State is 2-19 successful SEC games since 2023, including 1-12 nether second-year manager Jeff Lebby, yet nary visiting squad relishes playing successful Starkville. Just inquire Tennessee and Texas, some of which had to spell overtime earlier getting retired of municipality with wins.

Pick: Georgia 29-24.

Ducks are 6-0 successful Big Ten games played 2 oregon 3 clip zones distant from Eugene. Kinnick Stadium has a estimation for being inhospitable to ranked visiting teams. Hawkeyes volition marque this ugly.

Pick: Iowa 17-16.

BYU freshman QB Bear Bachmeier is simply a rising star, but helium hasn't been successful a roadworthy ambiance similar the 1 that awaits him successful Lubbock. Both teams are battling injuries.

Pick: Texas Tech 33-20.

Navy got its world cheque astatine North Texas past week and present goes connected the roadworthy again. The Fighting Irish, aft a closer-than-expected triumph astatine Boston College, don't privation to springiness the CFP committee a crushed to driblet them from No. 10 adjacent week.

Pick: Notre Dame 45-17.

Virginia has won 4 games by 1 people during its seven-game triumph streak. Wake Forest laid an ovum astatine Florida State past week and hopes it was a one-off.

Pick: Virginia 28-21.

Louisville's Isaac Brown is the ACC's second-leading rusher and averages a gaudy 8.59 yards per carry. That should interest a Cal defence that's fixed up 45 runs of 10-plus yards.

Pick: Louisville 31-10.

Auburn plays its archetypal crippled without fired manager Hugh Freeze. Tigers are 1-5 successful the SEC, and each of the games person been decided by nary much than 10 points. Commodores indispensable debar hangover from affectional nonaccomplishment astatine Texas.

Pick: Vanderbilt 24-16.

Hurricanes are poised to spell disconnected connected discourtesy aft being held to a season-low 20 points, their fewest successful 2 years, successful OT nonaccomplishment astatine SMU. Syracuse, loser of 5 straight, has superior issues connected some sides of the ball.

Pick: Miami 43-10.

Trojans escaped Nebraska with a four-point triumph past week contempt a season-worst violative performance. Northwestern hasn't scored much than 22 points against a power-conference opponent.

Pick: USC 34-14.

The CFP committee enactment Memphis archetypal successful enactment for the Group of Five bid, and Tigers volition beryllium motivated to validate that spot.

Pick: Memphis 27-22.

Two teams headed antithetic directions. Jedd Fisch, manager of the 6-2 Huskies, mentioned this week that past year's nationalist champion, Ohio State, had 2 losses, truthful each goals stay intact. Badgers barrelling toward worst play since Barry Alvarez's archetypal squad went 1-10 successful 1990.

Pick: Washington 34-13.

Byes: No. 11 Oklahoma, No. 13 Texas, No. 16 Georgia Tech, No. 17 Utah, No. 21 Michigan, No. 23 Tennessee, No. 25 Cincinnati.

Last week: Straight-up — 12-5; Against dispersed — 9-8.

Season: Straight-up — 130-38; Against dispersed — 81-86-1.

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